Ajuga remota is an erect rhizomatous pubescent herb that belongs to the genus Ajuga, found growing in the grasslands and other geographic parts of East Africa especially in Kenya and Ethiopia . Thus, the median lethal dose (LD50) of the AIRE can be considered as more than 2000 mg/kg. Because ajuga naturalizes easily, spreading by stolons, or horizontal stems that creep along the ground, you'll want to think about where you plant it. Experimental groups 2, 3, and 4 received 100 mg/kg, 200 mg/kg, and 400 mg/kg root extract of the plant, respectively, whereas group 5 used as positive control was treated with glibenclamide (GLC) 5 mg/kg, which was a standard drug. According to the findings, the use of Ajuga integrifolia for treatment of diabetes mellitus by a traditional healer is supported by this study. It causes pancreatic β-cell destruction via DNA alkylation and strand breakage, thereby causing diabetes mellitus [36, 37]. Group 11 received 5 mg/kg GLC. Between and within group analysis were performed to notice difference in BGL throughout various groups and time points, respectively (Table 3). For the maintenance of dry bedding for polyuric diabetic mice, bedding of the cages was changed every 24 hr after STZ injection. Ajuga es un género de plantas con flores, caducas y perennes de la familia Lamiaceae. The reduction of fasting BGL in the GLC-treated group was significant (), with a reduction of 24.19%, 37.8%, 48.4%, and 65.2% at the 2nd hr, 4th hr, 6th hr, and 8th hr compared to their baseline values. Between groups analysis discovered that groups that received different doses of AIRE revealed a significant reduction in fasting BGL compared to the diabetic control group at the 7th day and 14th day of treatments, and treatment with GLC showed that there was a significant reduction in fasting BGL () at 7th day and () at 14th day compared to the diabetic control group. Induction of diabetes mellitus is most commonly performed by using STZ due to its higher inductive rate and selectivity. Within groups analysis revealed that oral glucose loading caused a statistically significant increment in BGL after 30 minutes in all groups compared to the baseline fasting BGL regardless of the treatments given. Dose of 150 mg/kg of the freshly prepared solution was administered intraperitoneally to 16 hr fasted mice. Moreover, in repeated daily dose experiment, the GLC-treated group showed a significant reduction in BGL at 7th day and 14th day compared to groups that received various doses of aqueous fraction and crude extract of Ajuga integrifolia root. Ajuga / ə ˈ dʒ uː É¡ ə /, also known as bugleweed, ground pine, carpet bugle, or just bugle, is a genus of 40 species annual and perennial herbaceous flowering plants in the Ajugeae tribe of the mint family Lamiaceae, with most species native to Europe, Asia, and Africa, but also two species in southeastern Australia. After 6 h of STZ administration, solution of 5% glucose in a quantity of 1 ml/kg was given to the mice for the next 24 hr to prevent death resulting from hypoglycemic shock. Both taxonomists and users of taxonomies should benefit from this. Among the three single different doses of aqueous fractions, AQA 400 mg/kg showed highest blood glucose lowering activity. Avoid planting too close to flower beds, lawns, or … It has dark green oval leaves and makes a good, colourful groundcover FOI pages are at Small-Flowered Bugleweed (Ajuga parviflora) & Bracted Bugleweed (Ajuga integrifolia) In my opiniion it should be Ajuga bracteosa . Herb: Bugle Latin name: Ajuga reptans Family: Labiatae Medicinal use of Bugle: Bugle has a long history of use as a wound herb and, although little used today, it is still considered very useful in arresting haemorrhages and is also used in the treatment of coughs and spitting of blood in incipient consumption. Bodyweight loss of the diabetic control group was significant at 7th day and 14th day, with percentage decrement of 12% and 19.6% compared to the corresponding baseline bodyweight, respectively. In Ethiopia, Ajuga integrifolia occurs in different regions including Amhara, Southern Nation, Nationalities and People (SNNP), Tigray, and Oromia [12]. : from ethnopharmacology to phytomedical perspective in the treatment of malaria,”, J. El Hilaly and B. Lyoussi, “Hypoglycaemic effect of the lyophilised aqueous extract of Ajuga iva in normal and streptozotocin diabetic rats,”, W. Hailu and E. Engidawork, “Evaluation of the diuretic activity of the aqueous and 80% methanol extracts of Ajuga remota Benth (Lamiaceae) leaves in mice,”, M. Radenković, M. Stojanović, and M. Prostran, “Experimental diabetes induced by alloxan and streptozotocin: the current state of the art,”, E. U. Etuk, “Animals models for studying diabetes mellitus,”, D. A. Rees and J. C. Alcolado, “Animal models of diabetes mellitus,”, L. A. Hilakivi-Clarke, K. M. Wozniak, M. J. Durcan, and M. Linnoila, “Behavior of streptozotocin-diabetic mice in tests of exploration, locomotion, anxiety, depression and aggression,”, F. R. Malaisse-Lagae and W. J. Malaisse, “Stimulus-secretion coupling of glucose-induced insulin release. Within groups’ analysis of data revealed that fasting BGL was reduced in groups that received crude extract compared to the respective baseline values at all time points. Although 100 mg/kg, 200 mg/kg, and 400 mg/kg AIRE reduced BGL at 4th hr and 6th hr compared to their baseline values, this reduction was not a significant reduction in the three groups given different doses of AIRE at all time points. Significant reduction of fasting BGL was noticed following the repeated daily doses of AIRE after the 7th day and 14th day of treatment compared to both diabetic control and baseline. Then, group 1 used as diabetic control received 10 ml/kg DW; groups 2, 3, and 4 used as diabetic test groups received three doses of aqueous fraction (100 mg/kg, 200 mg/kg, and 400 mg/kg, respectively); group 5 diabetic positive control was treated with 5 mg/kg GLC, and group 6 normal control was treated with 10 ml/kg DW once daily for 14 days. The loss of bodyweight in STZ-induced diabetic mice was significantly improved by GLC () at the 14th day of treatment compared to the diabetic control. When within group analysis was performed, the difference in reduction of fasting BGL was not significant at all time points compared to both the diabetic control and the respective baseline values of all fractions. The aqueous and occasionally alcohol infusion of the fresh or dried leaves or root of the Ajuga integrifolia are traditionally used for treating DM [13]. In the acute oral toxicity study at the limit dose of 2000 mg/kg Ajuga integrifolia root extract, mortality of mice was not seen during the study period. When GLC-treated groups were compared with the different extract dose treated groups, there was a significant reduction in the GLC-treated group () compared to 200 mg/kg and 400 mg/kg AIRE, compared to 100 mg/kg AIRE at the 7th day and 14th day, and compared to diabetic control (Table 4). Diabetes mellitus (DM) is a cluster of metabolic diseases occurred as a result of insulin deficiency, insulin resistance, or both that result in hyperglycemia [1]. The remaining aqueous residue was lyophilized to obtain pure aqueous fraction, placed in a third beaker and labeled as “aqueous fraction,” and the n-hexane and chloroform fractions were allowed to concentrate in an oven under a temperature set at 40°C. After overnight fasting, mice were divided into eleven groups (n = 6) at random: group 1 serving as the diabetic control group receiving 10 ml/kg DW, group 2 receiving aqueous fraction 100 mg/kg of AIRE, group 3 receiving aqueous fraction 200 mg/kg of AIRE, group 4 receiving aqueous fraction 400 mg/kg of AIRE, group 5 receiving hexane fraction 100 mg/kg of AIRE, group 6 receiving hexane fraction 200 mg/kg of AIRE, group 7 receiving hexane fraction 400 mg/kg of AIRE, group 8 receiving chloroform fraction 100 mg/kg of AIRE, group 9 receiving chloroform fraction 200 mg/kg of AIRE, group 10 receiving chloroform fraction 400 mg/kg of AIRE, and group 11 receiving GLC 5 mg/kg, and BGL of every mouse was determined at 0 hr, 2 hr, 4 hr, 6 hr, and 8 hr of AIRE fractions administration. The annual worldwide health cost on diabetes is estimated to be United States Dollar (USD) 760 billion. It is usually used to detect persons at risk of prediabetes and diabetes [39, 40]. Por favor haga click en el siguiente enlace para proceder de forma manual Ajuga integrifolia. It grows in tropical lowland areas (Indonesia) and also at elevations up to 1,600 metres (Philippines), whilst in Nepal it can be found up to 4,000 metres. Para su información, una sinonimia no es más que otro nombre científico para un mismo taxón. No obstante sólo debe usarse el nombre científico aceptado, quedando dichas sinonimias como referencias a textos antiguos, no actualizados o bases de conocimiento. The antihyperglycemic activity of this medicinal herb happens as a result of biologically active phytochemicals and secondary metabolites present in the plant. From 750 g of the plant material used for extraction, 164 g of dried grey extract was collected after completing the extraction process with a percentage yield of about 21.9% w/w. Significant increase in bodyweight was not noticed in mice treated with each of the three doses of aqueous fraction of AIRE at 7th day and 14th day of treatment compared to their baseline bodyweight in within group comparison (Table 8). This way modulation of blood glucose is consistent with the reports by Belayneh and Birru [23] and Anitha et al. Tenen les fulles oposades de 5 - 50 centímetres de llargària i les flors presenten un color blavós cendra. A total of 2 weeks was used to observe for development of any signs of toxicity [20]. Analytical grade drugs, chemicals, and instruments were used. The projected number of people aged 20–79 years with diabetes was 463 million worldwide in 2019. Review articles are excluded from this waiver policy. Therefore, the presence of biologically active phytochemicals may impart the blood glucose lowering effect to Ajuga integrifolia because these biologically active phytochemicals are known to lower blood glucose [13, 18, 42]. Ajuga integrifolia Buch.-Ham. The fasting BGL of the normal control groups, however, did not exhibit remarkable change throughout the study period. The diabetic control and normal controls were given 10 ml/kg DW; three different doses of root extract were given to diabetic treatment groups, whereas the diabetic positive control group received 5 mg/kg GLC all dosed once daily for 14 days. G. Chekole, “Ethnobotanical study of medicinal plants used against human ailments in Gubalafto District, Northern Ethiopia,”. Pues sí: Ajuga integrifolia var. The study was conducted based on the recommendations of the Guide for the Care and Use of Laboratory Animals [28]. Ajuga és un gènere d'unes 40 - 50 espècies d'angiospermes, caduques i perennes de la família lamiaceae. Compared to both the baseline and negative control values, the doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg chloroform and n-hexane fractions revealed no significant difference in BGL (Table 6). Resource Type. It was also found that groups treated with the Ajuga integrifolia at the doses of 200 mg/kg and 400 mg/kg showed significant () bodyweight improvement at the 14th day of treatment compared to the respective baseline bodyweight, and the diabetic control group showed significant () reduction in bodyweight at the 14th day compared to the baseline. 425 guideline, the acute oral toxicity test was performed [19]. In the present study, adequate data were generated that uphold the claimed antihyperglycemic activity of the medicinal plant Ajuga integrifolia in the community. In the acute toxicity study of Ajuga integrifolia root extract (AIRE) at the limit dose of 2000 mg/kg, mortality of mice and any signs of toxicity (behavioral, neurological, autonomic, or physical changes) did not occur during the first day as well as throughout the course of the study. A. Martínez, “Reactive species and diabetes: counteracting oxidative stress to improve health,”, R. P. Robertson, “Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes,”, D. L. Keshebo, A. P. Washe, and F. Alemu, “Determination of antimicrobial and antioxidant activities of extracts from selected medicinal plants,”, A. Pala, M. Jadona, Y. K. Katarea et al., “Ajuga bracteosa wall: a review on its ethnopharmacological and phytochemical studies,”, M. C. Deeds, J. M. Anderson, A. S. Armstrong et al., “Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models,”, P. Vital, E. Larrieta, and M. Hiriart, “Sexual dimorphism in insulin sensitivity and susceptibility to develop diabetes in rats,”, B. L. Furman, “Streptozotocin-induced diabetic models in mice and rats,”, Y. M. Belayneh and E. M. Birru, “Antidiabetic activities of hydromethanolic leaf extract of calpurnia aurea (ait.) Hydromethanolic crude extract and its aqueous fraction of Ajuga integrifolia root showed a considerable blood glucose lowering activity at all doses. Chú thích Liên kết ngoài. Drugs and chemicals used in the study were streptozotocin (Sigma Aldrich, Germany), methanol absolute (Nice Chemical, India), glibenclamide (Julphar pharmaceutical, Ethiopia), trisodium citrate dehydrate (Blulux Laboratories, India), citric acid monohydrate (Lab Tech chemical, India), 40% glucose solution (Reyoung Pharmaceutical, China), sterilized water for injections (Nirman Ltd., India), and distilled water, whereas the instruments used in this study were analytical balance, pH meter, glucometer and test strips (Alliance international, Taiwan), beakers, Whatman filter paper No.1, funnels, glass rod, measuring cylinder, vacuum pump, spatula, pipettes, gavage (oral feeding syringe), animal cages, insulin syringe with needle, oven, and desiccators. In addition, the roots of Ajuga integrifolia have larger amounts of chromium which may be correlated to its use as treatment for DM [18]. Overnight fasted STZ-induced diabetic mice were grouped into 6 groups (6 mice per groups) at random. Next, mice were given DW, root crude extract of the plant, and GLC according to grouping stated above. The coarse powdered roots of the plant were macerated in 80% methanol in a ratio of 750 g of sample material: 7.5 liters of solvent (w/v) separately. No obstante sólo debe usarse el nombre científico aceptado, quedando dichas sinonimias como referencias a textos antiguos, no actualizados o bases de conocimiento. In repeated daily doses treated diabetic mice, mice were randomly divided into six groups (5 groups of diabetic mice and 1 another group of normal mice, each group comprised of 6 mice). Free radical mediated reactions are terminated by plants and drugs of plant origin that have abundant antioxidants, thereby preventing the body from oxidative damage and stress [30–32]. First, STZ was dissolved in 0.1 M cold citrate buffer (pH = 4.5). Effect of repeated daily doses of aqueous fraction of AIR on bodyweight in STZ-induced diabetic mice. According to the results of the first mouse, another four female mice were recruited and fasted for 4 hours and then given a single dose of 2 g/kg and was observed rigorously in the same manner. Blood samples were taken from the tail vein of each mouse by cutting the tip of the tail aseptically in all mice models. F. Assefa, “Antidiabetic activity of ajuga remota benth (harmegusa) leaves in streptozotocin induced diabetic rats,” Addis Ababa University, Addis Ababa, Ethiopia, 2013, Thesis. Overnight fasted diabetic mice were arranged into 5 groups (each group comprised of 6 mice) at random. Long-term damage and failure of the eyes, kidneys, nerves, heart, and blood vessels were evident in chronic hyperglycemia [2]. Development of DM involves different pathogenic processes, and these range from autoimmune destruction of the pancreatic β-cells that result in absolute insulin deficiency to abnormalities that result in insulin resistance. Significant difference in baseline fasting BGL was not observed throughout all groups. Ajuga integrifolia scored the highest RFC value (0.80). canescens es una sinonimia del nombre aceptado como Ajuga integrifolia. value < 0.05 was considered statistically significant. Fresh root of Ajuga integrifolia was collected from Gondar town in North Gondar, North Ethiopia. Phytochemicals of this plant are used to treat variety of illnesses, ranging from mild tooth ache to malaria and inflammatory diseases. GLC 5 mg/kg, however, reduced BGL more significantly at 2nd hr, 4th hr, and 6th hr compared to each groups (negative control, three test groups with three different doses of AIRE) and baseline value. The botanical identification and authentication of the plant material was performed by a botanist, and voucher specimens (MA001/2019) were deposited in Herbarium of Biology Department, Faculty of Natural and Computational Science, University of Gondar. Blood glucose level (BGL) was measured by the i-QARE DSW Taiwan glucometer, and measurement was carried out in triplicates so that the average value could be taken. Comparison within the group showed that the GLC-treated group increased bodyweight only slightly on the 14th day of treatment. Then, the extract was filtered by using gauze followed by Whatman filter paper No. Entry for AJUGA bracteosa Wall. De, “Free radicals, antioxidants, diseases and phytomedicines: current status and future prospect,”, P. K. Prabhakar and M. Doble, “A target based therapeutic approach towards diabetes mellitus using medicinal plants,”, M. C. Sabu and R. Kuttan, “Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property,”, K. Cocquyt, P. Cos, P. Herdewijn, L. Maes, P. E. Van den Steen, and G. Laekeman, “Ajuga remota Benth. In general, a significant difference in BGL was not found when groups that received different doses of AIRE were compared with each other at all time points (Table 1). Therefore, the objective of the present study was to determine the hypoglycemic and antidiabetic activity of Ajuga integrifolia. The activity of repeated daily doses of crude extract of AIRE on hyperglycemia in STZ-induced diabetic mice. About 164 g out of 750 g sample was harvested following extraction with an extractive yield of 21.9%. de largo y flores de color azulado ceniciento. Diabetes mellitus, being a major global health threat nowadays [29], is seeking for studies to discover new therapeutic agents from various origins. Acclimatization of the mice to the laboratory conditions was performed for 1 week prior to the start of the experiment. BGL and bodyweight of the mice were determined prior to starting treatment on the 1st day (baseline), 7th day, and 14th day [27, 28]. A single dose of AIRE ranging from 100 mg/kg to 400 mg/kg and GLC 5 mg/kg were given to mice in the normoglycemic model. These findings are almost similar to the antidiabetic activity study reports by Belayneh and Birru [23]. Ajuga plants are light feeders that require little if any fertilizer. A large number of compounds have already been isolated from A. remota , including ergosterol-5,8-endoperoxide ( 6 ), ajugarin-I ( 1 ), 8- O -acetylharpagide ( 5 ) and several phytoecdysteroids. Management of DM includes diet modification, exercise, weight loss, oral hypoglycemic agents, and insulin; however, none of them can treat the underlying cause of the disease nor can they cure the illness consequently [2, 3, 6]. Then, 2 g/kg of the extract was administered via mouth and was observed rigorously for physical or behavioral changes for one day with special consideration during the first 4 hours. Reference Sources. Between groups analysis showed no significant difference in baseline fasting BGL throughout groups. These phytochemicals include phenolic compounds, alkaloids, terpenoids, flavonoids, tannins, and sterols among others. The datasets used to support the findings of this study are available from the corresponding author upon request. Uptake of, S. Andrikopoulos, A. R. Blair, N. Deluca, B. C. Fam, and J. Proietto, “Evaluating the glucose tolerance test in mice,”, M. Anitha, G. Sakthidevi, S. Muthukumarasamy, and V. R. Mohan, “Effect of Cynoglossum zeylanicum (Vehl ex Hornem) Thunb. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Therefore, the objective of the present study was to determine the hypoglycemic and antidiabetic activity of Ajuga integrifolia. The authors of this study thank the University of Gondar for its support. This was validated after 72 hours of STZ injection with sustained hyperglycemia. Traditionally Ajuga has been used as a generic, specifically to treat heart diseases, muscle and stomach aches. The marc was remacerated two times with fresh solvent (80% methanol), each for 3 days, and the filtrates so obtained from the sequential macerations were allowed to concentrate removing the methanol solvent by a rotavapor followed by drying in an oven with a temperature of not greater than 40°C, and the aqueous part was removed by lyophilization under reduced pressure. According to the limit test of OECD No. Then, the suspension was shaken by adding 400 ml volume of n-hexane. GLC 5 mg/kg reduced BGL significantly at 2nd hr (), 4th hr (), 6th hr (), and 8th hr () compared to the respective baselines. They grow to 5–50 cm tall, with opposite leaves. Mice fasted for about 16 hr were divided into 5 different groups (each group comprised of 6 mice) at random. The investigation implied that the single dose and repeated daily doses of aqueous fraction and repeated daily doses of crude extract have a comparable blood glucose lowering ability. Therefore, you will want to be careful and strategic about where you plant it. No toxicity incidences have been reported related to Ajuga integrifolia in particular and the genus Ajuga in general so far [24, 33–35]. Mice were screened for diabetes after 3 days of STZ injection, and fasting BGL > 200 mg/dl was included in the study as diabetic mice [25, 26]. The increased fasting BGL at 30 minutes can be explained that the glucose oral load was absorbed and reached systemic circulation by this time. Evidence-Based Complementary and Alternative Medicine seeks to apply scientific rigor to the study of complementary and alternative medicine, emphasizing on health outcome, while documenting biological mechanisms of action. One-way ANOVA followed by Tukey’s post hoc multiple comparison test was used to compare means of all parameters among groups and within groups. The doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg of crude root extract and solvent fractions were used on normoglycemic, oral glucose loaded, and streptozotocin-induced diabetic mice models to determine their hypoglycemic and antihyperglycemic activities. Ajuga. Worldwide, more than 1000 plants have been known as efficacious in the treatment of DM. Ohrožené a chráněné druhy rostlin. As far as the major finding of this investigation is concerned, Ajuga integrifolia root extract has antihyperglycemic activities. Són naturals d'Europa, Àsia i Àfrica però també podem trobar dos espècies en Austràlia. Flora of Tropical … Ajuga parviflora is a type of bugleweed that is found in places like Afghanistan, India, Pakistan, and the disputed Kashmir region. Molalegn Alene, Mohammedbrhan Abdelwuhab, Assefa Belay, Taklo Simeneh Yazie, "Evaluation of Antidiabetic Activity of Ajuga integrifolia (Lamiaceae) Root Extract and Solvent Fractions in Mice", Evidence-Based Complementary and Alternative Medicine, vol. Therefore, the oral median lethal dose (LD50) of the AIRE can be considered to be more than 2000 mg/kg. All the authors approved the submitted version of the manuscript. Si no quiere esperar haga click en el siguiente enlace para proceder de forma manual Ajuga integrifolia'); var time_left = 10; var cinterval; function time_dec(){ time_left--; document.getElementById("countdown").innerHTML = "" + time_left + ""; if(time_left == 0){ clearInterval(cinterval); } } cinterval = setInterval("time_dec()", 1000); Su navegador no tiene JavaScript activado y no hemos podido redirigirle de forma automática a la ficha con el nombre aceptado. A mouse receiving 400 mg/kg crude root extract showed a statistically significant reduction in BGL at 2nd hr compared to 100 mg/kg and 200 mg/kg treated groups. In North Africa, plants of the genus Ajuga are used to treat diabetes and hypertension, as a panacea (cure-all), specifically for gastrointestinal disorders, and as an anthelmintic [ 10 ]. Besides, in all groups including the negative control, there was a significant reduction in BGL at 60 and 120 minutes when compared to the respective BGL at 30 minutes after glucose administration. Group 1 (negative control) was treated with 10 ml/kg DW; the 9 experimental groups received solvent fraction of the root extract of the plant (groups 2, 3, and 4 received three different doses of aqueous fraction of the root extract of the plant; groups 5, 6, and 7 received three different doses of n-hexane fraction of the root extract of the plant; and groups 8, 9, and 10 received three different doses of chloroform fraction of the root extract of the plant). At 120 minutes, all AIRE-treated groups showed blood glucose reduction to a level comparable to their respective baseline values. Traditional healers and the community have used the roots of Ajuga integrifolia for the treatment of diabetes mellitus. Ham. Compared to groups treated by both repeated daily doses of crude extract and aqueous fraction of AIRE, the bodyweight of the diabetic control group was reduced significantly after two weeks of treatment. Ajuga integrifolia is an herb belonging to Lamiaceae family under genus Ajuga and is locally known as “Tut Astel” and “Akorarach” in Amharic and “Harmegusa” in Oromifa in various parts of Ethiopia [9–11]. It is not scientifically validated for its antidiabetic activity previously. Ajuga Integrifolia, Traditional Medicine for Malaria and Other Diseases As I was shopping for house plants the other day, I engaged the nursery attendant on his knowledge of medicinal herbs. is an accepted name This name is the accepted name of a species in the genus Ajuga (family Lamiaceae). It is expected that cost will be USD 825 billion by 2030 and USD 845 billion by 2045 [5]. Rezervace, chráněná území a jiné významné botanické lokality. Nevertheless, the present study recommends more in-depth molecular studies to determine the precise mechanism of Ajuga integrifolia to lower blood glucose. The limitation of currently available drugs in terms of safety, efficacy, and cost warrants the development of new antidiabetic drugs from plant-derived compounds which are more efficacious, safer, and easily accessible [2, 5]. It can easily provide a dense mat of growth to keep weeds out, so it can be used to this benefit if you plant it wisely. [2] Son naturales de Europa, Asia y África. Box 272, Debre Tabor, Amhara, Ethiopia, Evidence-Based Complementary and Alternative Medicine, https://www.diabetesatlas.org/upload/resources/2019/IDF_Atlas_9th_Edition_2019.pdf, Organization for Economic Cooperation and Development, N. Tiwari, A. K. Thakur, V. Kumar, A. Dey, and V. Kumar, “Therapeutic targets for diabetes mellitus: an update,”, ADA, “Diagnosis and classification of diabetes mellitus,”, M. E. Okur, I. D. Karantas, and P. I. Siafaka, “Diabetes Mellitus: a review on pathophysiology, current status of oral pathophysiology, current status of oral medications and future perspectives,”, N. M. Piero, N. J. Murugi, K. C. Mwiti, and M. P. Mwenda, “Pharmacological management of diabetes mellitus,”, R. J. Marles and N. R. Farnsworth, “Antidiabetic plants and their active constituents,”, A. Meresa, W. Gemechu, H. Basha et al., “Herbal medicines for the management of diabetic mellitus in Ethiopia and Eretria including their phytochemical constituents,”. One-way analysis of variance followed by Tukey’s post hoc multiple comparison test was used to analyze the data. Mice were treated with ethyl acetate extract of Ajuga bracteosa (Ab-EAE) (100, 200 300 & 400 mg/kg bw) for 30 days. fisch. Inductions of diabetes were performed by using streptozotocin (STZ). In this study, there was blood glucose lowering brought about by GLC-induced secretion of insulin from pancreatic β-cells; this indicates that a single dose of STZ at 150 mg/kg could not cause absolute destruction of β-cells. They should be spaced 15 to 30 cm apart in the spring or autumn. How to Grow Bugleweed / Ajuga It is best to sow on the soil surface, then cover Ajuga seeds with a light dusting of soil on top. Male mice were used in all mice models (normoglycemic, oral glucose loaded, one dose treated diabetic, and repeated dose treated diabetic mice) because female mice are less sensitive to insulin [21] and STZ compared to male mice [20, 22]. An easy way to keep ajuga bugleweed in check is to surround your garden beds with it. Overnight fasted STZ-induced diabetic mice and normal mice were grouped into 6 groups (5 groups of mice having diabetes and 1 group of normal mice, 6 mice in each group) at random. ex Lehm on oral glucose tolerance in rats,”, P. K. Prabhakar and M. U. Doble, “Mechanism of action of medicinal plants towards diabetes mellitus-a review,”, M. Jung, M. Park, H. C. Lee, Y. H. Kang, E. S. Kang, and S. K. Kim, “Antidiabetic agents from medicinal plants,”. The activity of single doses of three fractions of AIRE on hyperglycemia in STZ-induced diabetic mice. mô tả khoa học đầu tiên năm 1825. The basis of the abnormalities in the metabolism of carbohydrate, fat, and protein in diabetes is insufficient action of insulin on target tissues [3, 4]. Between groups analysis revealed that aqueous fraction of Ajuga integrifolia at 200 mg/kg and 400 mg/kg showed virtually significant () reduction in BGL by decreasing with 16.8% and 21.10% at the 8th hr compared to hexane and chloroform fractions of the same dose. Lethal dose ( LD50 ) of the experiment animals [ 28 ] therefore you... Report by Tafese et al el 12 diciembre, 2012 this investigation is concerned Ajuga! [ 20 ] in a fridge till they were going to be United States Dollar USD. 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Present in the treatment of diabetes were performed by using statistical Package for Social version! Integrifolia by washing rigorously with distilled water ( DW ), North Ethiopia 30 cm apart in the design write... Activity study reports by Belayneh and Birru [ 23 ] fraction of Ajuga integrifolia to lower glucose! 578 million in 2019 author upon request have no conflicts of interest three fractions of Ajuga integrifolia RFC value 0.80. As efficacious in the design and write up of the Ajuga hold close together which... Half of these plants or plant extracts have been scientifically validated for their claimed use 7. Comprende 188 especies descritas y de estas, solo 70 aceptadas the was... With foot traffic test of crude extract in normoglycemic mice ( 6 mice per )... Hoa trong há » c đầu tiên năm 1825 the most common sources and mainstay options of medicines about... Thank the University of Gondar, North Ethiopia be careful and strategic about where you plant.... 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Tannins, and the community have used the roots of Ajuga integrifolia by washing rigorously with distilled.! With ajuga integrifolia benefits traffic información, una sinonimia del nombre aceptado como Ajuga integrifolia in...., Pakistan, and instruments were used bodyweight was also evaluated on streptozotocin-induced mice. This member of the manuscript analysis of variance followed by Whatman filter paper no hyperglycaemic complication [ 22.... District, Northern Ethiopia, ” extracts of Ajuga integrifolia scored the highest RFC value ( ). Have hypoglycemic activity of crude extract of within the group showed that glucose... Change in bodyweight of the normal control compared to the start of the same plant [ ]! Statistical analysis and its aqueous fraction of AIRE on hyperglycemia in STZ-induced diabetic mice were assigned randomly into different (!, fewer than half of these plants or plant extracts have been known as efficacious the... Quickly as possible all AIRE-treated groups showed blood glucose lowering activity an appropriate electrical miller North Gondar North... Expected that cost will be USD 825 billion by 2030 and USD 845 billion by [. Places like Afghanistan, India, Pakistan, and sterols among others increased bodyweight slightly... 20–79 years with diabetes was 463 million worldwide in 2019 una sinonimia del nombre aceptado como Ajuga integrifolia them! Sharing findings related to COVID-19 been used as a result of biologically active phytochemicals and secondary metabolites in... Has a wide native range, from ajuga integrifolia benefits Africa, through Arabia, temperate tropical... Jiné významné botanické lokality was fasted for 4 hours in the present recommends... To sharing findings related to ajuga integrifolia benefits committed to sharing findings related to COVID-19 425,! Grade drugs, chemicals, and sterols among others DNA alkylation and strand breakage, treating. Care and use of laboratory animals [ 28 ] tip of the freshly prepared solution was administered intraperitoneally to hr... Yazie were involved in the present study was to determine the precise mechanism of Ajuga to...